학술논문
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial
Document Type
Article
Author
Devereaux, P J; Duceppe, Emmanuelle; Guyatt, Gordon; Tandon, Vikas; Rodseth, Reitze; Biccard, Bruce M; Xavier, Denis; Szczeklik, Wojciech; Meyhoff, Christian S; Vincent, Jessica; Franzosi, Maria Grazia; Srinathan, Sadeesh K; Erb, Jason; Magloire, Patrick; Neary, John; Rao, Mangala; Rahate, Prashant V; Chaudhry, Navneet K; Mayosi, Bongani; de Nadal, Miriam; Iglesias, Pilar Paniagua; Berwanger, Otavio; Villar, Juan Carlos; Botto, Fernando; Eikelboom, John W; Sessler, Daniel I; Kearon, Clive; Pettit, Shirley; Sharma, Mukul; Connolly, Stuart J; Bangdiwala, Shrikant I; Rao-Melacini, Purnima; Hoeft, Andreas; Yusuf, Salim; Devereaux, P.J.; Duceppe, Emmanuelle; Bangdiwala, Shrikant I.; Connolly, Stuart; Eikelboom, John; Guyatt, Gordon; Kearon, Clive; Pettit, Shirley; Pogue, Janice; Rodseth, Reitze; Sessler, Daniel I.; Vincent, Jessica; Yusuf, Salim; Vincent, Jessica; Di Diodato, Sara; Gasic, Zora; Mastrangelo, Louise J.; Molnar, Sarah H.; Pettit, Shirley; Swanson, Jennifer L.; Tosh, Makayla L.; Wells, Jennifer R.; Botto, Fernando; Diaz, Rafael; Chow, Clara K.; Berwanger, Otavio; Gonzales, Beatriz; Devereaux, P.J.; Tandon, Vikas; Villar, Juan Carlos; Vásquez, Skarlet; Jansky, Petr; Dušek, Radovan; Meyhoff, Christian S.; Coriat, Pierre; Hoeft, Andreas; Wittmann, Maria; Yonga, Gerald; Xavier, Denis; Rao, Mangala; Mathur, Nandini; Franzosi, Maria Grazia; Seletti, Elena; Malaga, German; Tumanan-Mendoza, Bernadette A.; Tagle, Maria Pamela A.; Szczeklik, Wojciech; Biccard, Bruce M.; Alonso-Coello, Pablo; Popova, Ekaterine; Shields, Martin; Sessler, Daniel I.; Devereaux, P.J.; Biccard, Bruce M.; Connolly, Stuart; Duceppe, Emmanuelle; Eikelboom, John; Guyatt, Gordon; Hoeft, Andreas; Jansky, Petr; Kearon, Clive; Le Manach, Yannick; Moayyedi, Paul; Pettit, Shirley; Pogue, Janice; Rodseth, Reitze; Sessler, Daniel I.; van Zanten, Sander; Villar, Juan Carlos; Vincent, Jessica; Yusuf, Salim; Devereaux, P.J.; Alonso-Coello, Pablo; Berwanger, Otavio; Biccard, Bruce M.; Botto, Fernando; Chow, Clara K.; Connolly, Stuart; Coriat, Pierre; Diaz, Rafael; Duceppe, Emmanuelle; Eikelboom, John; Fleischmann, Edith; Franzosi, Maria Grazia; Garg, Amit; Guyatt, Gordon; Hoeft, Andreas; Jansky, Petr; Karaye, Kamilu; Kearon, Clive; Le Manach, Yannick; Malaga, German; McFalls, Edward; Meyhoff, Christian S.; Moayyedi, Paul; Pettit, Shirley; Pogue, Janice; Rodseth, Reitze; Sessler, Daniel I.; Sigamani, Alben; Shields, Martin; Szczeklik, Wojciech; Tumanan-Mendoza, Bernadette A.; van Zanten, Sander; Villar, Juan Carlos; Vincent, Jessica; Xavier, Denis; Yonga, Gerald; Yusuf, Salim; Connolly, Stuart; Belley-Côté, Emilie; Biedroń, Grzegorz; Borges, Flavia; Frosi Stella, Steffan; Haarmark Nielsen, Christian; Leong, Darryl P.; Meyhoff, Christian S.; Spence, Jessica; Tran, Allen; Wawrzycka-Adamczyk, Katarzyna; Yang, Stephen S.; Yung, Terence; Wyse, D. George; Cheng, Davy; Johnstone, David E.; Wells, George A.; Joseph, Philip; Patel, Ameen; Leong, Darryl P.; Gregus, Krysten; Lawrence, Kelly; Doharris, Lindsay; Conen, David; Cheung, Jason; Douketis, Jim; Wright, Douglas; Wikkerink, Spencer; Dechert, William; Panju, Mohamed; Azzam, Khalid; Rapanos, Theodore; Van Helder, Tomas; Shroff, Anjali; Hare, Jacqueline; Kidane, Biniam; Nguyen, Thang; Leydier, Larissa; Bayaraa, Vanessa; Parlow, Joel; DuMerton, Deborah A.; Thakrar, Amar; Shelley, Jessica; Deligne, Benoit; Carling, Roberta Daila; Mrkobrada, Marko; Dresser, George K.; Jacka, Michael J.; Garg, Amit; Hornstein, David; Winkelaar, Gerrit B.; Haider, Zoeb Hussain; Lanjewar, Pravina Prashant; Varughese, Valsamma; Calton, Rajneesh; Ahuja, Hemani; George, Preetha; Sharma, Ambika; Bhatt, Keyur Sureshchandra; Mangukiya, Dhaval Odhavajibhai; Nandaniya, Karshan Vira; Parekh, Viral Vasantrai; Pillai, Ashok Bhaskaran; Menon, Vidya P.; Desai, Sanjay Channappa; Sidhu, Ravinder Singh; Gupta, Sandeep Kumar; George, Robbie K.; Gurunath, T.R.; Drummond, Leanne W.; Torborg, Alexandra M.; Küsel, Belinda S.; Naidoo, Prebashini; Naidoo, Datshana P.; Rajah, Chantal; Farina, Zane; von Rahden, Richard Peter; Gumede, Simphiwe; Chishala, Chishala; Coetzee, Ettienne; Dyer, Robert A.; Diedericks, Johan; Bielański, Piotr; Kaczmarek, Bogusz; Studzińska, Dorota; Zaniewski, Maciej; Libura, Marek Józef; Zacharias-Nalichowski, Tomasz Mikołaj; Sega, Aurelia A.S.; Salwa, Jakub; Kózka, Mateusz; Górka, Jacek; Wludarczyk, Anna; Nowak-Kózka, Ilona; Grudzień, Paweł Szczepan; Gucwa, Jaroslaw W.; Słowiaczek, Michał Piotr; Dobosz, Paweł P.D.; Gögenur, Ismail; Eriksen, Jens Ravn; Borup, Tine; Kirkegaard, Tove; Isbye, Dan; Sonne, Asger; Rasmussen, Lars S.; Pedersen, Sofie; Troensegaard, Hannibal; Duus, Camilla L.; Halle, Benedikte M.; Gundel, Ossian N.; Bernholm, Katrine F.; Martinsen, Kristian Rønsholt; Pedersen, Søren; Itenov, Theis S.; Camio, Elena; Vázquez, Carles; Matarin, Silvia; Cano, Esther; Álvarez-García, Jesús; India, Inmaculada; González-Osuna, Aránzazu; Vives, Marc; Rosselló, Elena; Serrano, Ana B.; Turiel, Maurizio; Drago, Lorenzo; Colombo, Chiara; Marra, Federica; Mos, Lucio; Arteni, Franco; Lembo, Rosalba; Ortalda, Alessandro; Passarani, Simonetta; Mokini, Zhirajr; Figueiredo, Estevao Lanna; Werner, Gustavo Fonseca; Petriz, Joao Luiz; Maia, Lilia Nigro; Bergo, Ricardo R.; Precoma, Dalton Bertolim; Saraiva, José Francisco Kerr; Vilamajo, Oscar Gomez; Allegrini, Eduardo; Benzadón, Mariano; Parody, Maria Leonor; Duronto, Ernesto A.; Ingaramo, Adrián C.; Parra, Gustavo Adolfo; Novoa, Danny; Miller, Scott A.; Thomas, Sabu; Karlapudi, Sudhakar P.; Bourji, Mohamad H.; Banerjee, Subhash; Gupta, Anita; Opole, Isaac O.; Fischer, Michal; Jansky, Petr; Mendoza, Victor Lecaros; Reyes, Eugenio Borja; Pierson, Richard J.; Shields, Martin O.; Chow, Clara K.; Coriat, Pierre; Piriou, Vincent; Wittmann, Maria; Zacharowski, Kai; Yonga, Gerald; Rotta-Rotta, Aida; Paper, Main; Devereaux, P.J.; Duceppe, Emmanuelle; Guyatt, Gordon; Tandon, Vikas; Rodseth, Reitze; Biccard, Bruce M.; Xavier, Denis; Szczeklik, Wojciech; Meyhoff, Christian S.; Vincent, Jessica; Franzosi, Maria Grazia; Srinathan, Sadeesh K.; Erb, Jason; Magloire, Patrick; Neary, John; Rao, Mangala; Rahate, Prashant; Chaudhry, Navneet; Mayosi, Bogani; de Nadal, Miriam; Paniagua Iglesias, Pilar; Berwanger, Otavio; Villar, Juan Carlos; Botto, Fernando; Eikelboom, John; Sessler, Daniel I.; Kearon, Clive; Pettit, Shirley; Sharma, Mike; Connolly, Stuart; Bangdiwala, Shrikant I.; Rao-Melacini, Purnima; Hoeft, Andreas; Yusuf, Salim
Source
The Lancet; June 2018, Vol. 391 Issue: 10137 p2325-2334, 10p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Myocardial injury after non-cardiac surgery (MINS) increases the risk of cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran prevents perioperative venous thromboembolism, but whether this drug can prevent a broader range of vascular complications in patients with MINS is unknown. The MANAGE trial assessed the potential of dabigatran to prevent major vascular complications among such patients.