학술논문
Survey of spiking in the mouse visual system reveals functional hierarchy
Document Type
Article
Author
Siegle, Joshua H.; Jia, Xiaoxuan; Durand, Séverine; Gale, Sam; Bennett, Corbett; Graddis, Nile; Heller, Greggory; Ramirez, Tamina K.; Choi, Hannah; Luviano, Jennifer A.; Groblewski, Peter A.; Ahmed, Ruweida; Arkhipov, Anton; Bernard, Amy; Billeh, Yazan N.; Brown, Dillan; Buice, Michael A.; Cain, Nicolas; Caldejon, Shiella; Casal, Linzy; Cho, Andrew; Chvilicek, Maggie; Cox, Timothy C.; Dai, Kael; Denman, Daniel J.; de Vries, Saskia E. J.; Dietzman, Roald; Esposito, Luke; Farrell, Colin; Feng, David; Galbraith, John; Garrett, Marina; Gelfand, Emily C.; Hancock, Nicole; Harris, Julie A.; Howard, Robert; Hu, Brian; Hytnen, Ross; Iyer, Ramakrishnan; Jessett, Erika; Johnson, Katelyn; Kato, India; Kiggins, Justin; Lambert, Sophie; Lecoq, Jerome; Ledochowitsch, Peter; Lee, Jung Hoon; Leon, Arielle; Li, Yang; Liang, Elizabeth; Long, Fuhui; Mace, Kyla; Melchior, Jose; Millman, Daniel; Mollenkopf, Tyler; Nayan, Chelsea; Ng, Lydia; Ngo, Kiet; Nguyen, Thuyahn; Nicovich, Philip R.; North, Kat; Ocker, Gabriel Koch; Ollerenshaw, Doug; Oliver, Michael; Pachitariu, Marius; Perkins, Jed; Reding, Melissa; Reid, David; Robertson, Miranda; Ronellenfitch, Kara; Seid, Sam; Slaughterbeck, Cliff; Stoecklin, Michelle; Sullivan, David; Sutton, Ben; Swapp, Jackie; Thompson, Carol; Turner, Kristen; Wakeman, Wayne; Whitesell, Jennifer D.; Williams, Derric; Williford, Ali; Young, Rob; Zeng, Hongkui; Naylor, Sarah; Phillips, John W.; Reid, R. Clay; Mihalas, Stefan; Olsen, Shawn R.; Koch, Christof
Source
Nature; April 2021, Vol. 592 Issue: 7852 p86-92, 7p
Subject
Language
ISSN
00280836; 14764687
Abstract
The anatomy of the mammalian visual system, from the retina to the neocortex, is organized hierarchically1. However, direct observation of cellular-level functional interactions across this hierarchy is lacking due to the challenge of simultaneously recording activity across numerous regions. Here we describe a large, open dataset—part of the Allen Brain Observatory2—that surveys spiking from tens of thousands of units in six cortical and two thalamic regions in the brains of mice responding to a battery of visual stimuli. Using cross-correlation analysis, we reveal that the organization of inter-area functional connectivity during visual stimulation mirrors the anatomical hierarchy from the Allen Mouse Brain Connectivity Atlas3. We find that four classical hierarchical measures—response latency, receptive-field size, phase-locking to drifting gratings and response decay timescale—are all correlated with the hierarchy. Moreover, recordings obtained during a visual task reveal that the correlation between neural activity and behavioural choice also increases along the hierarchy. Our study provides a foundation for understanding coding and signal propagation across hierarchically organized cortical and thalamic visual areas.