학술논문
Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial
Document Type
Article
Author
Pitisuttithum, Punnee; Nitayaphan, Sorachai; Chariyalertsak, Suwat; Kaewkungwal, Jaranit; Dawson, Peter; Dhitavat, Jittima; Phonrat, Benjaluck; Akapirat, Siriwat; Karasavvas, Nicos; Wieczorek, Lindsay; Polonis, Victoria; Eller, Michael A; Pegu, Poonam; Kim, Dohoon; Schuetz, Alexandra; Jongrakthaitae, Surat; Zhou, Yingjun; Sinangil, Faruk; Phogat, Sanjay; Diazgranados, Carlos A; Tartaglia, James; Heger, Elizabeth; Smith, Kirsten; Michael, Nelson L; Excler, Jean-Louis; Robb, Merlin L; Kim, Jerome H; O'Connell, Robert J; Vasan, Sandhya; Pitisuthitham, Arom; Sabmee, Yupa; Sirisopana, Narongrid; Eamsila, Chirapa; Savaraj, Prapaporn; Labwech, Wanlaya; Teerachia, Siriluck; Chotirosniramit, Nuntisa; Supindham, Taweewat; Pruenglampoo, Boonlure; Sugandhavesa, Patcharaphan; Kosashunhanan, Natthapol; Kaewthip, Oranitcha; Sroysuwan, Piyathida; Jarujareet, Pawinee; Ratto-Kim, Silvia; Molnar, Sebastian; Schoen, Jesse; Churikanont, Nampueng; Getchalarat, Saowanit; Sangnoi, Nongluck; Nuntapinit, Bessara; Phramtong, Anant; Grandin, Pornsuk V.; Madnote, Sirinan; Rittiroongrad, Surawach; Kaewboon, Boot; Trichavaroj, Rapee; Puangkaew, Jiraporn; Chantakulkij, Somsak; Rakyat, Phiromrat; Panjapornsuk, Pornchanok; Tragonlugsana, Nipattra; Chuenarom, Weerawan; de Souza, Mark; Ngauy, Viseth; Phanuphak, Nittaya; Chomchey, Nitiya; Saengtawan, Puttachard; Teeratakulpisarn, Nipat; Rerknimitr, Rungsun; Kroon, Eugene; Lee, Carter A.; Chinaworapong, Suchada
Source
The Lancet HIV; April 2020, Vol. 7 Issue: 4 pe238-e248, 11p
Subject
Language
ISSN
24054704; 23523018
Abstract
The RV144 phase 3 vaccine trial in Thailand demonstrated that ALVAC-HIV (vCP1521) and AIDSVAX B/E administration over 6 months resulted in a 31% efficacy in preventing HIV acquisition. In this trial, we assessed the immunological effect of an additional vaccine boost to the RV144 regimen at varying intervals between the priming vaccine series and the boost.