학술논문
Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs
Document Type
Article
Author
Trasande, Leonardo; Nelson, Morgan E; Alshawabkeh, Akram; Barrett, Emily S; Buckley, Jessie P; Dabelea, Dana; Dunlop, Anne L; Herbstman, Julie B; Meeker, John D; Naidu, Mrudula; Newschaffer, Craig; Padula, Amy M; Romano, Megan E; Ruden, Douglas M; Sathyanarayana, Sheela; Schantz, Susan L; Starling, Anne P; Hamra, Ghassan B; Smith, PB; Newby, KL; Jacobson, LP; Catellier, DJ; Gershon, R; Cella, D; Cordero, J; Tylavsky, F; Mason, A; Zhao, Q; Bush, N; LeWinn, KZ; Lyall, K; Volk, H; Schmidt, R; Kerver, JM; Barone, C; Fussman, C; Paneth, N; Elliott, M; Nguyen, R; Swan, S; Karr, C
Source
The Lancet Planetary Health; February 2024, Vol. 8 Issue: 2 pe74-e85, 12p
Subject
Language
ISSN
25425196
Abstract
Phthalates are synthetic chemicals widely used in consumer products and have been identified to contribute to preterm birth. Existing studies have methodological limitations and potential effects of di-2-ethylhexyl phthalate (DEHP) replacements are poorly characterised. Attributable fractions and costs have not been quantified, limiting the ability to weigh trade-offs involved in ongoing use. We aimed to leverage a large, diverse US cohort to study associations of phthalate metabolites with birthweight and gestational age, and estimate attributable adverse birth outcomes and associated costs.