학술논문
Trends in Pulmonary Embolism Deaths Among Young Adults Aged 25 to 44 Years in the United States, 1999 to 2019.
Document Type
Academic Journal
Author
Zuin M; Department of Translational Medicine, University of Ferrara, Ferrara, Italy. Electronic address: zuinml@yahoo.it.; Bikdeli B; Cardiovascular Medicine Division and Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Yale/YNHH Center for Outcomes Research and Evaluation, New Haven, Connecticut.; Armero A; Cardiovascular Medicine Division and Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Porio N; Cardiovascular Medicine Division and Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Rigatelli G; Department of Cardiology, Ospedali Riuniti Padova Sud, Monselice, Italy.; Bilato C; Department of Cardiology, West Vicenza Hospital, Arzignano, Italy.; Piazza G; Cardiovascular Medicine Division and Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Source
Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0207277 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1913 (Electronic) Linking ISSN: 00029149 NLM ISO Abbreviation: Am J Cardiol Subsets: MEDLINE
Subject
Language
English
Abstract
A concerning increase in mortality from acute pulmonary embolism (PE) in young adults in the United States has been reported. We extracted PE-related mortality rates (number of deaths per US population) from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database from 1999 to 2019, focusing on subjects aged 25 to 44 years. Age-adjusted mortality rates (AAMRs) were assessed using the Joinpoint regression modeling and expressed as the estimated average annual percentage change (AAPC) with relative 95% confidence intervals (95% CIs) and stratified by urbanization, gender, age, and race. Between 1999 and 2019, the AAMR from acute PE in US adults aged 25 to 44 years linearly increased without any difference between genders (AAPC +1.5%, 95% CI 1.2 to 1.8, p <0.001). AAMR increase was more pronounced in American-Indians/Alaska Natives and in Asian/Pacific Islanders (AAPC +2.5%, 95% CI 1.6 to 3.4, p <0.001), Whites (AAPC +1.7%, 95% CI 1.4 to 2.0, p <0.001), Latinx/Hispanic patients (AAPC +1.7%, 95% CI 0.6 to 3.0, p = 0.003), and residents of rural areas (AAPC +2.4%, 95% CI 1.9 to 2.8, p <0.001). A higher AAMR (4.02 per 100,000 residents, 95% CI 3.90 to 4.15) and absolute number of PE-related deaths were observed in the South. PE-related mortality in adults aged 25 to 44 years has increased over the last 2 decades in the United States. Stratification by race, ethnicity, urbanization, and census region showed ethnoracial and regional disparities that will require further evaluation and remedy.
Competing Interests: Declaration of Competing Interest Dr. Bikdeli reports that he is a consulting expert, on behalf of the plaintiff, for litigation related to 2 specific brand models of IVC filters. Dr. Bikdeli is supported by the Scott Schoen and Nancy Adams IGNITE Award and the Mary Ann Tynan Research Scientist award through the Mary Horrigan Connors Center for Women's Health and Gender Biology, and the Heart and Vascular Center Junior Faculty Award, all at Brigham and Women's Hospital. Dr. Bikdeli is a recipient of a Career Development Award from the American Heart Association and VIVA Physicians (No. 938814). Dr. Piazza has received research support from Bristol-Myers Squibb/Pfizer Alliance, Bayer, Janssen, Alexion, Amgen, and Boston Scientific Corporation and consulting fees from Pfizer, Boston Scientific Corporation, Janssen, and Amgen. The remaining authors have no conflicts of interest to declare.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of Competing Interest Dr. Bikdeli reports that he is a consulting expert, on behalf of the plaintiff, for litigation related to 2 specific brand models of IVC filters. Dr. Bikdeli is supported by the Scott Schoen and Nancy Adams IGNITE Award and the Mary Ann Tynan Research Scientist award through the Mary Horrigan Connors Center for Women's Health and Gender Biology, and the Heart and Vascular Center Junior Faculty Award, all at Brigham and Women's Hospital. Dr. Bikdeli is a recipient of a Career Development Award from the American Heart Association and VIVA Physicians (No. 938814). Dr. Piazza has received research support from Bristol-Myers Squibb/Pfizer Alliance, Bayer, Janssen, Alexion, Amgen, and Boston Scientific Corporation and consulting fees from Pfizer, Boston Scientific Corporation, Janssen, and Amgen. The remaining authors have no conflicts of interest to declare.
(Copyright © 2023 Elsevier Inc. All rights reserved.)