학술논문
Abnormal carnitine metabolism in hemodialysis patients on different anticoagulants.
Document Type
Academic Journal
Author
Sekiguchi K; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Abe T; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Shiomi E; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Ikarashi D; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Matsuura T; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Maekawa S; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Kato R; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Kanehira M; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Takata R; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Sugimura J; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.; Sekiguchi T; Sekiguchi Internal Clinic, Hachinohe, Japan.; Obara W; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan.
Source
Publisher: Blackwell Pub Country of Publication: Australia NLM ID: 101181252 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-9987 (Electronic) Linking ISSN: 17449979 NLM ISO Abbreviation: Ther Apher Dial Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: We aimed to determine whether unfractionated heparin (UH) and low molecular weight heparin (LH) contribute to aberrant carnitine metabolism in patients receiving hemodialysis.
Methods: The rate of increase in serum free fatty acids (FFAs) and the ratio of acylcarnitine to free carnitine (AC/FC) from before to after hemodialysis were determined in patients receiving UH and LH. Additionally, the effect of switching patients to UH from LH was examined.
Results: AC/FC was significantly higher in the UH group. In addition, serum FFAs in that group increased to 0.825 ± 0.270 after dialysis from 0.172 ± 0.160 before dialysis, showing a positive correlation with AC/FC. Furthermore, AC/FC was observed to be significantly higher in patients who were switched to UH from LH at 3 months after the change.
Conclusion: Compared with UH, LH has a lesser effect on lipid metabolism, suggesting that it also has a lesser effect on carnitine metabolism.
(© 2023 International Society for Apheresis and Japanese Society for Apheresis.)
Methods: The rate of increase in serum free fatty acids (FFAs) and the ratio of acylcarnitine to free carnitine (AC/FC) from before to after hemodialysis were determined in patients receiving UH and LH. Additionally, the effect of switching patients to UH from LH was examined.
Results: AC/FC was significantly higher in the UH group. In addition, serum FFAs in that group increased to 0.825 ± 0.270 after dialysis from 0.172 ± 0.160 before dialysis, showing a positive correlation with AC/FC. Furthermore, AC/FC was observed to be significantly higher in patients who were switched to UH from LH at 3 months after the change.
Conclusion: Compared with UH, LH has a lesser effect on lipid metabolism, suggesting that it also has a lesser effect on carnitine metabolism.
(© 2023 International Society for Apheresis and Japanese Society for Apheresis.)