학술논문
Orbitostriatal encoding of reward delayed gratification and impulsivity in chronic pain.
Document Type
Academic Journal
Author
Cerqueira-Nunes M; Instituto de Investigação e Inovação em Saúde (i3S) - Pain Neurobiology Group, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Faculdade de Medicina, Departamento de Biomedicina - Unidade de Biologia Experimental (FMUP), Universidade do Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal; Programa doutoral em Neurociências (PDN), Faculdade de Medicina, Universidade do Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.; Monteiro C; Instituto de Investigação e Inovação em Saúde (i3S) - Pain Neurobiology Group, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Faculdade de Medicina, Departamento de Biomedicina - Unidade de Biologia Experimental (FMUP), Universidade do Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.; Galhardo V; Instituto de Investigação e Inovação em Saúde (i3S) - Pain Neurobiology Group, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Faculdade de Medicina, Departamento de Biomedicina - Unidade de Biologia Experimental (FMUP), Universidade do Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.; Cardoso-Cruz H; Instituto de Investigação e Inovação em Saúde (i3S) - Pain Neurobiology Group, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Faculdade de Medicina, Departamento de Biomedicina - Unidade de Biologia Experimental (FMUP), Universidade do Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal. Electronic address: hcruz@med.up.pt.
Source
Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
Subject
Language
English
Abstract
Central robust network functional rearrangement is a characteristic of several neurological conditions, including chronic pain. Preclinical and clinical studies have shown the importance of pain-induced dysfunction in both orbitofrontal cortex (OFC) and nucleus accumbens (NAc) brain regions for the emergence of cognitive deficits. Outcome information processing recruits the orbitostriatal circuitry, a pivotal pathway regarding context-dependent reward value encoding. The current literature reveals the existence of structural and functional changes in the orbitostriatal crosstalk in chronic pain conditions, which have emerged as a possible underlying cause for reward and time discrimination impairments observed in individuals affected by such disturbances. However, more comprehensive investigations are needed to elucidate the underlying disturbances that underpin disease development. In this review article, we aim to provide a comprehensive view of the orbitostriatal mechanisms underlying time-reward dependent behaviors, and integrate previous findings on local and network malplasticity under the framework of the chronic pain sphere.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)