부산대학교 도서관

The objectives of the present study are to prepare and produce betacarroten s contained NLCs, and survey the effect of surfactant concentration a nd lipid: oil ratio on the particle size and stability of betacarotene NLC . The Hot-High shear Homogenizer (Hot-HSH ( technique was applied to produce NLC dispersions and the optimum formulation determined with different circumstances change, such as surfactant concentration (2, 3, 4 and 6% w/v) and lipid:oil ratio (Compritol ATO 888/ octyl octanoate) in 2:1I4:1 and 10:1. Various testes such as particle size, mor phology and stability carried out to determine physicochemical properties of formulations. NLCs prepared at 3% (w/v) poloxamer 407 concentration and at 10:1 ratio of compritol (solid lipid) to octyl o ctanoate (liquid oil ( containing 2% (w/v) beta carotene concentration sho wed significantly lower particle size and narrow particle size distribution (73 nm and span = 0.684, respectively). The results showed tha t an optimum concentration of 3% of Poloxamer 407 was sufficient to cover the surface of nanoparticles efficiently and use 10:1 ratio of solid lipid liquid oil showed significantly lower particle size compar e to other ratios . The production of betacarroten-contained NLCs was a n efficacious method in terms of encapsulation, nanoscale particle size decrease, st ability within time and other expected [ABSTRACT FROM AUTHOR]