학술논문
Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure (BioVAT-DZHK20): Trial Design and Experience at UKSH Lübeck.
Document Type
Article
Author
Source
Subject
*HEART failure
*MYOCARDIUM
*INDUCED pluripotent stem cells
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Language
ISSN
0171-6425
Abstract
The article discusses the BioVAT-HF trial, which aims to investigate the use of induced pluripotent stem cell-derived Engineered Human Myocardium (EHM) as "Biological Ventricular Assist Tissue" (BioVAT) in patients with advanced heart failure. The trial involves the implantation of EHM in patients with terminal heart failure and evaluates its safety and efficacy. The study reports the experience of enrolling patients at the University Heart Center Luebeck (UKSH) and highlights that the implantation of EHM was feasible and apparently safe. However, one patient died of progressive cardio-renal failure after the procedure. [Extracted from the article]