학술논문
New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.
Document Type
Journal Article
Author
Hoogerwerf, Marie-Astrid; Coffeng, Luc E; Brienen, Eric A T; Janse, Jacqueline J; Langenberg, Marijke C C; Kruize, Yvonne C M; Gootjes, Chelsea; Manurung, Mikhael D; Dekker, Mark; Becker, Luke; Erkens, Marianne A A; Beek, Martha T van der; Ganesh, Munisha S; Feijt, Carola; Winkel, Beatrice M F; Westra, Inge M; Meij, Pauline; Loukas, Alex; Visser, Leo G; Vlas, Sake J de
Source
Subject
*HOOKWORMS
*EXCRETION
*VACCINE effectiveness
*EGGS
*NEMATODE physiology
*ANIMAL experimentation
*BIOLOGICAL models
*BLOOD cell count
*COMPARATIVE studies
*EOSINOPHILS
*FECES
*HOOKWORM disease
*INSECT larvae
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*NEMATODES
*PROBABILITY theory
*RESEARCH
*EVALUATION research
*HUMAN research subjects
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Language
ISSN
0022-1899
Abstract
Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies. [ABSTRACT FROM AUTHOR]