학술논문
Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?
Document Type
Article
Author
Mizuguchi, Toru; Torigoe, Toshihiko; Satomi, Fukino; Shima, Hiroaki; Kutomi, Goro; Ota, Shigenori; Ishii, Masayuki; Hayashi, Hiroshi; Asakura, Sumiyo; Hirohashi, Yoshihiko; Meguro, Makoto; Kimura, Yasutoshi; Nishidate, Toshihiko; Okita, Kenji; Ishino, Masaho; Miyamoto, Atsushi; Hatakenaka, Masamitsu; Sato, Noriyuki; Hirata, Koichi
Source
Subject
*PANCREATIC duct
*CLINICAL drug trials
*PANCREATIC cancer
*MEDICAL protocols
*VACCINATION
*CANCER
*PROGNOSIS
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Language
ISSN
0941-1291
Abstract
Pancreatic tumors are chemoresistant and malignant, and there are very few therapeutic options for pancreatic cancer, as the disease is normally diagnosed at an advanced stage. Although attempts have been made to develop vaccine therapies for pancreatic cancer for a couple of decades, none of the resultant protocols or regimens have succeeded in improving the clinical outcomes of patients. We herein review vaccines tested within the past few years, including peptide, biological and multiple vaccines, and describe the three sets of criteria used to evaluate the therapeutic activity of vaccines in solid tumors. [ABSTRACT FROM AUTHOR]