학술논문
Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks.
Document Type
Article
Author
Source
Subject
*HETEROCYCLIC compounds synthesis
*DIMETHYL sulfoxide
*METHYLATION
*RADICALS (Chemistry)
*DEUTERATION
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*
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*
Language
ISSN
1359-7345
Abstract
The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope of the developed method for the synthesis of various scaffolds was demonstrated. [ABSTRACT FROM AUTHOR]