학술논문
Direct‐acting oral anticoagulants and alopecia: The valuable support of postmarketing data.
Document Type
Article
Source
Subject
*ANTICOAGULANTS
*BALDNESS
*ATRIAL fibrillation
*DRUG side effects
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Language
ISSN
0306-5251
Abstract
Little is known about the administration of direct‐acting oral anticoagulants (DOACs) and the occurrence of alopecia. Our aim was to analyse the reports of alopecia following DOAC administration received until 2 May 2018 from VigiBase, the World Health Organization database. A descriptive analysis of age, sex, seriousness and dechallenge/rechallenge outcome was carried out. For each report, the time‐to‐onset was evaluated and the causality was assessed by using Naranjo algorithm. Overall, 1316 reports were retrieved, most concerning rivaroxaban (58.8%); 80% of the reports were related to females, in particular to those aged ≥65 years (23.1%). The median value of the time‐to‐onset was 28 days, with an interquartile range of 63 days. In 54.3% of the reports the causality was assessed as possible. In conclusion, a possible association could exist between DOACs administration and alopecia, but further observational studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]