학술논문
Sensitivity of MUP parameters in detecting change in early ALS.
Document Type
Article
Source
Subject
*AMYOTROPHIC lateral sclerosis
*ELECTROMYOGRAPHY
*MUSCLE diseases
*AXONS
*CLINICAL trials
*DIAGNOSIS
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Language
ISSN
1388-2457
Abstract
Highlights: [•] Detailed knowledge on the earliest changes of the motor unit morphology in ALS is critical for evaluating reinnervation with electromyography, in future clinical trials with drugs promoting axonal sprouting. [•] Increased motor unit duration and jitter are very sensitive and consistent markers of early motor unit adaptation in very early affected muscles in ALS. [•] Mean motor unit duration is a measure easily applicable in clinical trials of compounds considered likely to be of value in promoting reinnervation. [Copyright &y& Elsevier]