학술논문
Visceral Leishmaniasis Masquerading as Drug-Induced Pancytopenia in Lung Cancer Patients.
Document Type
Article
Source
Subject
*VISCERAL leishmaniasis
*LUNG cancer
*NON-small-cell lung carcinoma
*MACROPHAGE activation syndrome
*CANCER patients
*PANCYTOPENIA
*DRUG side effects
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Language
ISSN
1198-0052
Abstract
Maintenance chemotherapy is a standard treatment in patients with non-progressive advance staged IV non-squamous non-small cell lung cancer after induction therapy. Here, we report the case of a 53-year-old man undergoing a maintenance monotherapy with pemetrexed who presented prolonged pancytopenia despite filgrastim injections. A bone marrow aspiration revealed a macrophage activation syndrome with Leishmania amastigotes. A Polymerase Chest Reaction testing confirmed the diagnosis of visceral leishmaniasis. Treatment with liposomal amphotericin B was started. Oncologists should bear in mind that visceral leishmaniasis in endemic areas can potentially induce severe and prolonged pancytopenia in immunosuppressed patients, during chemotherapy in particular. [ABSTRACT FROM AUTHOR]