부산대학교 도서관

The presented study is devoted to the structural and biological properties of four derivatives of fluorenylspirohydantoin based on experimental data. The crystal structure of one of those, (9ʹ-fluorene)-spiro-5-(2-thiohydantoin), is described. The compound crystallizes in monoclinic crystal system and P21/c space group. We have pursued isolation of single crystals and biological activity tests of (9ʹ-fluorene)-spiro-5-hydantoin, (9ʹ-fluorene)-spiro-5-(2,4-dithiohydantoin), (9ʹ-fluorene)-spiro-5-(2-thiohydantoin), and (4ʹ,5ʹ-diaza-9ʹ-fluorene)-spiro-5-hydantoin. The compounds have been tested in both adherent and suspension tumor cell lines. The cell proliferation has been assessed by the WST-assay (Roche Applied Science). The antimicrobial activity against both Gram-positive, Gram-negative bacteria, and the yeast Candida albicans has been studied. [ABSTRACT FROM AUTHOR]