학술논문
Global phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib.
Document Type
Article
Author
Source
Subject
*ACUTE myeloid leukemia
*BONE marrow
*PHOSPHORYLATION
*ACUTE myeloid leukemia treatment
*PROTEIN-tyrosine kinases
*PATIENTS
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Language
ISSN
0887-6924
Abstract
The article presents a study which analyzes the phosphoproteome of human bone marrow. It examines whether researchers can distinguish differentially regulated phospho-sites when equating non-responder and responder samples. The resulting final phospo-signature comprising of five phosphorylation sites separates strongly the classes of non-responder and responder samples.