학술논문
Identifying an obinutuzumab resistant subpopulation of monocyte-derived-macrophages from patients with CLL.
Document Type
Letter
Author
Source
Subject
*CHRONIC lymphocytic leukemia
*LYMPHOCYTIC leukemia
*ANTIBODY-dependent cell cytotoxicity
*CHRONIC leukemia
*PATTERN perception receptors
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Language
ISSN
1042-8194
Abstract
Antibody therapies are important treatment options for Chronic lymphocytic leukemia (CLL). Paradoxically, MDMs also play a critical role in tumor cell killing either through a) recognition and phagocytosis of tumor cells mediated I via i pattern recognition receptors [[6]] or b) Fc R-dependent phagocytosis of tumor cells that have been opsonized with a therapeutic antibody (e.g. obinituzumab) [[7]]. Given the evidence that macrophages are key effector cells that clear opsonized CLL cells [[9]] it is surprising that little attention has focused on characterizing the phenotype of the MDMs responsible. [Extracted from the article]