학술논문
Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome.
Document Type
Journal Article
Author
Source
Subject
*MYOSIN
*SMOOTH muscle
*GENETIC mutation
*COLON cancer
*ADENOMA
*MICROSATELLITE repeats
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Language
ISSN
0007-0920
Abstract
We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+). [ABSTRACT FROM AUTHOR]