학술논문
Electrochemical bromination of enamides with sodium bromide.
Document Type
Article
Source
Subject
*SODIUM bromide
*BROMINATION
*SUZUKI reaction
*METAL catalysts
*SYNTHETIC products
*SALT
*
*
*
*
*
Language
ISSN
1463-9262
Abstract
The electrochemical bromination of enamide derivatives was developed using inexpensive and non-toxic sodium bromide (NaBr). This transformation enabled the direct stereoselective formation of a C(sp2)−Br bond and was applied to a wide variety of enamides without the need for external hazardous oxidants, reductants or metal catalysts. The protocol showed a general efficiency and tolerance, allowing access to brominated enamides with yields ranging from 56% to 85%. The reaction conditions were applied to the chlorination reaction using sodium chloride (NaCl). The synthetic utility of the products was illustrated through Suzuki and Sonogashira cross-coupling reactions, offering a novel reaction procedure to access complex enamide derivatives. [ABSTRACT FROM AUTHOR]