학술논문

Recurrent autoimmune hypophysitis treated with rituximab: a case report.
Document Type
Journal Article
Source
Journal of Medical Case Reports. 12/14/2021, Vol. 15 Issue 1, p1-6. 6p.
Subject
*RITUXIMAB
*SCOTOMA
*MAGNETIC resonance imaging
*PITUITARY gland
*CD20 antigen
Language
ISSN
1752-1947
Abstract
Background: Autoimmune hypophysitis is a rare condition that often results in enlargement of the pituitary gland and hypopituitarism due to inflammatory infiltration. Management of autoimmune hypophysitis can include long-term hormonal replacement and close control of the inflammatory pituitary mass. Mass-related symptoms in patients with autoimmune hypophysitis are treated with anti-inflammatory therapy, surgery, and/or radiotherapy.Case Presentation: We present a 25-year-old White man with visual field defects of the right eye, headache, and weight loss. Magnetic resonance imaging showed a sellar mass, and the patient underwent transcranial surgery. Histopathology revealed autoimmune hypophysitis with predominantly CD20 positive B-cell infiltration. Progression of visual field defects necessitated postoperatively anti-inflammatory treatment with prednisolone. Azathioprine was initiated under gradual tapering of prednisolone with stable conditions at first, but relapse followed after dose reduction. Therefore, rituximab treatment was initiated, which resulted in regression of the pituitary mass. Rituximab treatment was discontinued after 25 months. The patient has continuously been in remission for 4 years after rituximab treatment was stopped.Conclusion: This case illustrates that rituximab might be an effective alternative treatment in B-cell predominant autoimmune hypophysitis. [ABSTRACT FROM AUTHOR]