부산대학교 도서관

The effect of IgA and IgG soluble immune complexes (SIC) on neutrophil chemotaxis was investigated. Six types of SIC were prepared from κ-type IgA and IgG myeloma proteins: IgA-anti-κ chain antibody SIC in IgA excess, IgA-anti-κ chain antibody in SIC in anti-κ chain antibody excess, IgA-anti-α chain antibody SIC in IgA excess, IgG-anti-κ chain antibody SIC in IgG excess, IgG-anti-κ chain antibody SIC in anti-κ chain antibody excess, and IgG-anti-γ chain antibody SIC in IgG excess. Three types of IgA SIC had a marked suppressive effect on neutrophil chemotaxis, while IgG SIC, free IgA, free anti-κ chain antibody, and free anti-γ chain antibody showed no inhibitory activity. This suppressive effect on neutrophil chemotaxis caused specifically by polymerized IgA was a cell-directed one and was expressed in a concentration dependent manner. [ABSTRACT FROM AUTHOR]