학술논문
Evidence for retinal neuronal dysfunction prior to breakdown of the blood‐retinal barrier or onset of vasculopathy in type I diabetes.
Document Type
Article
Author
Source
Subject
*DIABETIC retinopathy
*TYPE 1 diabetes
*VISION
*CONTRAST sensitivity (Vision)
*COLOR vision
*FLUORESCENCE angiography
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Language
ISSN
1755-375X
Abstract
Purpose To characterize visual function in type I diabetic patients prior to breakdown of the blood‐retinal barrier or onset of vasculopathy as compared with patients with early diabetic retinopathy (DR). Methods Visual function was assessed by Multifocal Electroretinography (RetiScan ‐ Roland Consult), Colour Vision (CCT ‐ Cambridge Research Systems) and Frequency‐Doubling Perimetry (FDT ‐ Zeiss) in a population of 42 patients (age=26.6+5.3 years) divided into 2 groups: with no DR (n=26; VA=1.088+0.128) and with mild nonproliferative DR (n=16; VA=1.093+0.137). Fluorescein angiography was also performed in order to determine the absence or presence of initial vascular lesions. These data were compared with age‐matched controls. Non‐parametric statistical analysis was performed at a significance cut‐off level of p<0.05. Results MfERG yielded a significant decrease in amplitude in all eccentricity rings in both patients groups, when compared with control subjects (p<0.0001). Interestingly, implicit time showed a paradoxical pattern between patient groups with a significant decrease in rings 2‐4 (0.002