부산대학교 도서관

Background: The technique of « en bloc» liver and small bowel transplantation (L‐BT) spares a biliary anastomosis, but does not protect against biliary complications. We analyze biliary and duodenal complications (BDC) in our pediatric series. Methods: Between 1994 and 2020, 54 L‐BT were performed in 53 children. The procurement technique included in situ vascular dissection and pancreatic reduction to the head until 2009 (group A). Thereafter, the whole pancreas was recovered (group B). Results: Nine BDCs occurred in 8/53 (15%) patients (7 in group A and 1 in group B): leak of the donor's duodenal stump (2), stenosis of the extra‐pancreatic bile duct (5), and intra‐pancreatic bile duct stenosis (2). Median delay for diagnosis of stricture was 8 months (4–168). Interventional radiology was successful in one child only, the others required reoperations. Two patients died, of biliary cirrhosis or cholangitis, 15‐month and 12‐year post‐L‐BT. One was listed and liver re‐transplanted 13 years post‐L‐BT. At last follow‐up, two patients only had normal liver tests and ultrasound. Conclusion: BDC after L‐BT can cause severe morbidities. Pancreatic reduction might increase this risk. Early surgical complications or chronic pancreatic rejection might be co‐factors. Early diagnosis and treatment are key to the long‐term prognosis. [ABSTRACT FROM AUTHOR]