부산대학교 도서관

I Sir i : The spectrum of Lynch syndrome (LS) is progressively widening, with an increasing number of tumour types being added to the list of "LS-related cancers" (sarcomas, uveal melanomas, etc.).[1] Urological neoplasms are the third most common tumours in LS patients, and most frequently occur in the upper urinary tract. A, Tumour cells with a diffuse growth pattern, crossed by fibrous septa filled with lymphocytes. Besides the presence of the I MSH2 i mutation in peripheral blood (Figure E), tumour tissue sequencing revealed the presence of the same mutation along with loss of heterozygosity at the I MSH2 i locus (Figure F). [Extracted from the article]