학술논문
Direct amidation of unprotected amino acids using B(OCH2 CF3 )3 .
Document Type
Article
Author
Source
Subject
*AMINO acid derivatives
*BORATE synthesis
*CHEMICAL synthesis
*CARBOXYLIC acids
*OLIGOMERS -- Structure
*AMIDATION
*DRUG factories
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Language
ISSN
1359-7345
Abstract
A commercially available borate ester, B(OCH2CF3)3, can be used to achieve protecting-group free direct amidation of α-amino acids with a range of amines in cyclopentyl methyl ether. The method can be applied to the synthesis of medicinally relevant compounds, and can be scaled up to obtain gram quantities of products. [ABSTRACT FROM AUTHOR]