학술논문
Tapering of the thrombopoietin receptor agonist in paediatric patients with chronic immune thrombocytopenia: Is it possible?
Document Type
Article
Author
Source
Subject
*THROMBOPOIETIN receptor agonists
*THROMBOPOIETIN receptors
*CHILD patients
*IDIOPATHIC thrombocytopenic purpura
*TERMINATION of treatment
*DISEASE relapse
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Language
ISSN
0306-5251
Abstract
It is not clear if platelet responses are sustained after thrombopoietin receptor agonist (ar‐TPO) withdrawal in paediatric patients. A multicentre retrospective observational study was performed in children with chronic immune thrombopenia (cITP) to describe ar‐TPO tapering and withdrawal in patients who had achieved a sustained complete response to ar‐TPOs. Ten patients (eltrombopag n = 6, romiplostim n = 4) were included. Treatment withdrawal was performed after a mean tapering time of 7.6 months. Two patients relapsed (median follow‐up time of 24 months). Slow tapering and withdrawal of ar‐TPOs can be safely performed in cITP paediatric patients after achieving a sustained complete response. [ABSTRACT FROM AUTHOR]