부산대학교 도서관

Background: Breast cancer is a heterogenous disease that impacts racial/ethnic groups differently. Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women. Materials and Methods: A population-based study was conducted in the city of Santiago de Compostela, Spain. A total of 645 women diagnosed with operable invasive breast cancer between 1992 and 2005 participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics of the tumors were collected. Hormone receptor negative tumors were compared with hormone receptor postive tumors on their clinico-pathological characteristics as well as risk factor profiles. Results: Among the 645 breast cancer patients, 78% were estrogen receptor-positive (ER+) or progesterone receptorpositive (PR+), and 22% were ER2&PR2. Women with a family history of breast cancer were more likely to have ER2&PR2 tumors than women without a family history (Odds ratio, 1.43; 95% confidence interval, 0.91-2.26). This association was limited to cancers diagnosed before age 50 (Odds ratio, 2.79; 95% confidence interval, 1.34-5.81). Conclusions: An increased proportion of ER2&PR2 breast cancer was observed among younger Spanish women with a family history of the disease. [ABSTRACT FROM AUTHOR]