학술논문
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans.
Document Type
Article
Author
Source
Subject
*IMMUNOGLOBULINS
*AUTOANTIBODIES
*EARLY diagnosis
*SQUAMOUS cell carcinoma
*RHEUMATOID arthritis
*ESOPHAGEAL cancer
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Language
ISSN
0009-9104
Abstract
Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in the serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our findings show that anti-GSTO1-1 antibodies can be found in a variety of inflammatory diseases, including autoimmune rheumatoid arthritis, infectious SARS-CoV-2, and trichinellosis. Our findings strongly suggest that anti-GSTO1-1 antibodies may be a marker of tissue damage/inflammation rather than a specific tumor-associated biomarker. [ABSTRACT FROM AUTHOR]