학술논문
Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial
Document Type
Article
Author
Kelley, Robin Kate; Ueno, Makoto; Yoo, Changhoon; Finn, Richard S; Furuse, Junji; Ren, Zhenggang; Yau, Thomas; Klümpen, Heinz-Josef; Chan, Stephen L; Ozaka, Masato; Verslype, Chris; Bouattour, Mohamed; Park, Joon Oh; Barajas, Olga; Pelzer, Uwe; Valle, Juan W; Yu, Li; Malhotra, Usha; Siegel, Abby B; Edeline, Julien; Vogel, Arndt; Akce, Mehmet; Ales Diaz, Inmaculada; Alves, Gustavo; Anand, Sumitra; Arslan, Cagatay; Asselah, Jamil; Assenat, Eric; Aubin, Francine; Bai, Li-Yuan; Bai, Yuxian; Barajas, Olga; Bates, Susan; Begbie, Stephen; Ben-Aharon, Irit; Beri, Nina; Berres, Marie-Luise; Blanc, Jean-Frederic; Borbath, Ivan; Bordonaro, Robert; Bouattour, Mohamed; Brandi, Giovanni; Burgoyne, Adam; Butthongkomvong, Kritiya; Camandaroba, Marcos; Cao, Ke; Carballido, Marcela; Chan, Stephan Lam; Chen, Jen-Shi; Chen, Ming-Huang; Chen, Xiaoming; Cheng, Ashley; Chiu, Tai-Jan; Choi, Hye Jin; Chon, Hong Jae; Collignon, Joelle; Cubillo Gracian, Antonio; Davis, Sarah; de Carvalho, Ricardo Saraiva; de Groot, D.J.A.; Demols, Anne; De Vos, Judith; Diab, Maria; Easaw, Jacob; Eatock, Martin; Edeline, Julien; Elias, Rawad; Eskens, Fredericus; Falcone, Alfredo; Fernandez, Plinio; Finn, Richard; Franke, Fabio; Furukawa, Masayuki; Furuse, Junji; Gbolahan, Olumide; Geboes, Karen; Geneser, Keri-Lee; Geng, Zhimin; Geva, Ravit; Gillmore, Roopinder; Goetze, Thorsten; Gou, Hongfeng; Grasselli, Julieta; Gu, Shanzhi; Gumus, Mahmut; Haj Mohammad, Nadia; Hao, Chunyi; Harputluoglu, Hakan; Hatoum, Hassan; Heinemann, Volker; Ho, Wang Kwong; Hsu, Chiun; Hubert, Ayala; Hwang, Juneul; Inanc, Mevlude; Iseas, Soledad; Jeyasingam, Vaishnavi; Jimenez Fonseca, Paula; Joubert, Warren; Juengsamarn, Jitlada; Kaen, Diego; Kanai, Masashi; Kasper-Virchow, Stefan; Kazemi, Ghazaleh; Kelleher, Fergal; Kelley, Robin; Kim, Jin Won; Kim, Jong Gwang; Kinupe Abrahao, Ana Beatriz; Klumpen, Heinz; Kochenderfer, Mark; Kose, Fatih; Lam, Ho Ching; Lee, Choong-kun; Lee, Hyun Woo; Lee, Margaret; Lee, Myung Ah; Lee, Wai Man Sarah; Le Sourd, Samuel; Li, Dongliang; Li, Wei; Liang, Houjie; Liang, Tingbo; Lim, Chun Sen; Lingerfelt, Brian; Lopez, Charles; Low, John; Macarulla Mercade, Teresa; Malka, David; Mao, Yimin; Masi, Gianluca; McCune, Steven; McDermott, Ray; McWhirter, Elaine; Mendez, Guillermo; Milella, Michele; Mizuno, Nobumasa; Mizutani, Tomonori; Moniz, Camila; Morales, Luisa; Munoz Martin, Andres Jesús; Nervi, Bruno; Ngamphaiboon, Nuttapong; Oh, Sang Cheul; Oksuzoglu, Berna; Outlaw, Darryl; Ozaka, Masato; Ozguroglu, Mustafa; Ozyilkan, Ozgur; Painemal, Claudio; Pan, Yueyin; Park, Joon Oh; Pelzer, Uwe; Peng, Chuang; Petorin, Caroline; Pezet, Denis; Power, Derek; Qin, Shukui; Ren, Zhenggang; Roohullah, Aflah; Ryu, Hyewon; Salman, Pamela; Sasaki, Mitsuhito; Sasidharan, Rita; Satoh, Taroh; Schulze, Kornelius; Scott-Brown, Martin; Segovia, Ruben; Seufferlein, Thomas; Siena, Salvatore; Sinapi, Isabelle; Smolenschi, Cristina; Song, Tianqiang; Sookprasert, Aumkhae; Soparattanapaisarn, Nopadol; Starling, Naureen; Stein, Stacey; Stemmer, Salomon; Su, Haichuan; Sugimoto, Rie; Suksombooncharoen, Thatthan; Tam, Vincent; Tan, Ai Lian; Tan, Chih Kiang; Tanasanvimon, Suebpong; Tonini, Giuseppe; Tortora, Giampaolo; Tsuji, Akihito; Ueno, Makoto; Uribe, Rodrigo; Venerito, Marino; Verdaguer Mata, Helena; Verslype, Chris; Victorino, Ana Paula; Vogel, Arndt; Wade, James; Waldschmidt, Dirk Thomas; Wang, Lu; Wan Isahk, Wan Zamaniah; Wasan, Harpeet; Weschenfelder, Rui; Wong, Chun Yin; Wong, Yoke Fui; Yalcin, Suayib; Yanez Weber, Patricio; Yang, Xuezhong; Yasui, Hisateru; Yau, Thomas; Yazici, Ozan; Yen, Chia-Jui; Ying, Jieer; Yoo, Changhoon; Yu, Wenchang; Zhao, Haitao
Source
The Lancet; June 2023, Vol. 401 Issue: 10391 p1853-1865, 13p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Biliary tract cancers, which arise from the intrahepatic or extrahepatic bile ducts and the gallbladder, generally have a poor prognosis and are rising in incidence worldwide. The standard-of-care treatment for advanced biliary tract cancer is chemotherapy with gemcitabine and cisplatin. Because most biliary tract cancers have an immune-suppressed microenvironment, immune checkpoint inhibitor monotherapy is associated with a low objective response rate. We aimed to assess whether adding the immune checkpoint inhibitor pembrolizumab to gemcitabine and cisplatin would improve outcomes compared with gemcitabine and cisplatin alone in patients with advanced biliary tract cancer.