학술논문
Association Between Whole Blood–Derived Mitochondrial DNA Copy Number, Low‐Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk
Document Type
article
Author
Liu, Xue; Sun, Xianbang; Zhang, Yuankai; Jiang, Wenqing; Lai, Meng; Wiggins, Kerri L; Raffield, Laura M; Bielak, Lawrence F; Zhao, Wei; Pitsillides, Achilleas; Haessler, Jeffrey; Zheng, Yinan; Blackwell, Thomas W; Yao, Jie; Guo, Xiuqing; Qian, Yong; Thyagarajan, Bharat; Pankratz, Nathan; Rich, Stephen S; Taylor, Kent D; Peyser, Patricia A; Heckbert, Susan R; Seshadri, Sudha; Boerwinkle, Eric; Grove, Megan L; Larson, Nicholas B; Smith, Jennifer A; Vasan, Ramachandran S; Fitzpatrick, Annette L; Fornage, Myriam; Ding, Jun; Carson, April P; Abecasis, Goncalo; Dupuis, Josée; Reiner, Alexander; Kooperberg, Charles; Hou, Lifang; Psaty, Bruce M; Wilson, James G; Levy, Daniel; Rotter, Jerome I; Bis, Joshua C; Consortium, TOPMed mtDNA Working Group in NHLBI Trans‐Omics for Precision Medicine; Satizabal, Claudia L; Arking, Dan E; Liu, Chunyu
Source
Journal of the American Heart Association. 12(20)
Subject
Language
Abstract
Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia). P