학술논문
Language and Reading Impairments Are Associated with Increased Prevalence of Non-Right-Handedness
Document Type
Journal Articles
Reports - Research
Reports - Research
Author
Abbondanza, Filippo (ORCID 0000-0002-1799-5492 ); Dale, Philip S. (ORCID 0000-0002-7697-8510 ); Wang, Carol A.; Hayiou-Thomas, Marianna E.; Toseeb, Umar (ORCID 0000-0002-7536-2722 ); Koomar, Tanner S.; Wigg, Karen G.; Feng, Yu; Price, Kaitlyn M.; Kerr, Elizabeth N.; Guger, Sharon L.; Lovett, Maureen W.; Strug, Lisa J.; van Bergen, Elsje (ORCID 0000-0002-5860-5745 ); Dolan, Conor V.; Tomblin, J. Bruce; Moll, Kristina; Schulte-Körne, Gerd; Neuhoff, Nina; Warnke, Andreas; Fisher, Simon E.; Barr, Cathy L.; Michaelson, Jacob J.; Boomsma, Dorret I.; Snowling, Margaret J. (ORCID 0000-0003-0836-3861 ); Hulme, Charles (ORCID 0000-0001-9499-5958 ); Whitehouse, Andrew J. O.; Pennell, Craig E.; Newbury, Dianne F.; Stein, John; Talcott, Joel B.; Bishop, Dorothy V. M.; Paracchini, Silvia (ORCID 0000-0001-9934-8602 )
Source
Subject
Language
English
ISSN
0009-3920
1467-8624
1467-8624
Abstract
Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6-19 years old; European ethnicity) using a priori set criteria. A meta-analysis (N[subscript cases] = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06-1.39, p = 0.01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.