학술논문
JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic properties in preclinical models
Document Type
Journal
Author
Brachmann, Saskia M.; Weiss, Andreas; Guthy, Daniel A.; Beyer, Kim; Voshol, Johannes; Maira, Michel; Prahallad, Anirudh; Porta, Diana Graus; Schnell, Christian; Ostermann, Nils; Vaupel, Andrea; Gerspacher, Marc; Leblanc, Catherine; Erdmann, Dirk; Sterker, Dario; Kerr, Grainne; Jerome, Giovannoni; Head, Victoria; Stringer, Rowan; De Kanter, Ruben; Jeff, Kearns; Roman, Danielle; Widmer, Toni; Wessels, Peter; Nunez, Eloisa Jimenez; Sedrani, Richard; Zecri, Frederic; Hofmann, Francesco; Engleman, Jeff; Lorthiois, Edwige; Cotesta, Simona
Source
Subject
Language
English
ISSN
15388514