학술논문
Cell specific radiation dosimetry in skeleton from life-span carcinogenesis studies. Final report
Document Type
Technical Report
Author
Source
Other Information: PBD: 5 Apr 1993
Subject
Language
English
Abstract
The osteogenic sarcoma is the dominant life-threatening pathology in lifespan studies of beagles exposed to alpha-emitting bone-seeking radionuclides. It was deduced from these studies that certain skeletal sites are more prone to develop tumors. This project sought to determine the bone cells at risk and their cell-specific radiation dose. The cell-specific radiation dose values are related to loss and high Ra-226 and Pu-239 induced osteogenic sarcoma sites, to test different dose response hypothesis and predict the extent of effects in humans.