학술논문
Modification of pH induced cellular inactivation by irradiation-glial cells
Document Type
Conference
Author
Source
Int. J. Radiat. Oncol., Biol. Phys.; (United States); 6:12; Conference: Meeting of the European Group of Hyperthermia in Radiation Oncology, Cambridge, England, 10 Sep 1979
Subject
Language
English
Abstract
Human cells of glial origin were examined for clonogenic survival after exposure to subnormal pH of the extracellular fluid for 0 to 5 days at 37/sup 0/C. The surviving fraction decreased at pH values between 6.7 and 6.4 to 10% within 2 days. Cells that survived irradiation demonstrated a decreased sensitivity to an acid extracellular fluid. The radiation response function was established with and without incubation at pH 6.7 for 66 hours. Doses above 4 Gray resulted in a higher survival at pH 6.7 than at pH 7.4, if pH was reduced 15 hours prior to irradiation. Enhanced clonogenic survival after irradiation under conditions of continuous acidity in the extracellular space may be a further explanation for poor local control of malignant tumors in clinical radiation therapy.