부산대학교 도서관

Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disease with the main symptom of bone pain. In the case of a recurrent multifocal course, it is referred to as chronic recurrent multifocal osteomyelitis (CRMO), which mainly affects girls and patients between the ages of 7 and 12 years. If skin symptoms in the form of acne also occur (particularly in adolescents/adults and males), this is referred to as the synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. It is not yet clear whether CNO and SAPHO syndrome actually represent a common entity.The skin symptoms of SAPHO syndrome are mainly manifested as acne conglobata on the face, neck, back and upper extremities or as psoriasis. The pustulosis is manifested as pustules on the palms of the hands and soles of the feet. A genetic component appears to play a role as there are case reports of siblings and identical twins and patients with CRMO often also suffer from chronic inflammatory bowel disease. These are mainly associated with a multifocal occurrence and bone lesions in the pelvic region.The pathophysiology of the disease has not been definitively clarified. It is known that an imbalance between proinflammatory and anti-inflammatory cytokines occurs in a variety of ways.