학술논문
Peripheral and lung resident memory T cell responses against SARS-CoV-2
Document Type
Original Paper
Author
Grau-Expósito, Judith; Sánchez-Gaona, Nerea; Massana, Núria; Suppi, Marina; Astorga-Gamaza, Antonio; Perea, David; Rosado, Joel; Falcó, Anna; Kirkegaard, Cristina; Torrella, Ariadna; Planas, Bibiana; Navarro, Jordi; Suanzes, Paula; Álvarez-Sierra, Daniel; Ayora, Alfonso; Sansano, Irene; Esperalba, Juliana; Andrés, Cristina; Antón, Andrés; Ramón y Cajal, Santiago; Almirante, Benito; Pujol-Borrell, Ricardo; Falcó, Vicenç; Burgos, Joaquín; Buzón, María J.; Genescà, Meritxell
Source
Nature Communications. 12(1)
Subject
Language
English
ISSN
2041-1723
Abstract
Resident memory T cells (TRM ) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, TRM are mostly non-recirculating, which reduces the window of opportunity to examine these cells in the blood as they move to the lung parenchyma. Here, we identify circulating virus-specific T cell responses during acute infection with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome. Disease severity is associated predominantly with IFNγ and IL-4 responses, increased responses against S peptides and apoptosis, whereas non-hospitalized patients have increased IL-12p70 levels, degranulation in response to N peptides and SARS-CoV-2-specific CCR7+ T cells secreting IL-10. In convalescent patients, lung-TRM are frequently detected even 10 months after initial infection, in which contemporaneous blood does not reflect tissue-resident profiles. Our study highlights a balanced anti-inflammatory antiviral response associated with a better outcome and persisting TRM cells as important for future protection against SARS-CoV-2 infection.
Lung resident memory T (TRM ) cells are important for protection from viral infection in the lungs. Here the authors use paired lung biopsy material and blood to characterize T cell responses in patients with COVID-19 over time and find persistence of antiviral lung TRM cells that might be important to limit reinfection.
Lung resident memory T (T