부산대학교 도서관

Objective: To assess whether β-glucan (which is fermented in the colon) lowers postprandial glucose concentrations through mechanisms distinct from a delayed carbohydrate absorption and inhibits de novo lipogenesis.Design: Administration of frequent small meals each hour over 9 h allows a rate of intestinal absorption to be reached which is independent of a delayed absorption. A group of 10 healthy men received either an isoenergetic diet containing 8.9 g/day β-glucan or without β-glucan for 3 days. On the third day, the diet was administered as fractioned meals ingested every hour for 9 h.Setting: Laboratory for human metabolic investigations.Subjects: Ten healthy male volunteers.Main outcome measures: Plasma glucose and insulin concentrations, glucose kinetics, glucose oxidation, de novo lipogenesis.Results: On the third day, plasma glucose and free fatty acid concentrations, carbohydrate and lipid oxidation, and energy expenditure were identical with β-glucan and cellulose. Plasma insulin concentrations were, however, 26% lower with β-glucan during the last 2 h of the 9 h meal ingestion. Glucose rate of appearance at steady state was 12% lower with β-glucan. This corresponded to a 21% reduction in the systemic appearance rate of exogenous carbohydrate with β-glucan, while endogenous glucose production was similar with both diets. De novo lipogenesis was similar with and without β-glucan.Conclusion: Administration of frequent meals with or without β-glucan results in similar carbohydrate and lipid metabolism. This suggests that the lowered postprandial glucose concentrations which are observed after ingestion of a single meal containing β-glucan are essentially due to a delayed and somewhat reduced carbohydrate absorption from the gut and do not result from the effects of fermentation products in the colon.European Journal of Clinical Nutrition (2001) 55, 327–333