학술논문
Role of IL33 in chronic inflammation and microvascular damage as a reflection of organ damage on a cohort of patients with acromegaly
Document Type
Original Paper
Author
Source
Journal of Endocrinological Investigation: Official Journal of Italian Society of Endocrinology (SIE). :1-7
Subject
Language
English
ISSN
1720-8386
Abstract
Aim: Acromegaly is a rare chronic disease, caused by the over-secretion of growth hormone (GH), that creates a pro-inflammatory state, but the exact mechanisms by which GH or insulin-like growth factor 1 (IGF-1) act on inflammatory cells are not fully understood. Aim of the study was to evaluate Interleukin-33 (IL33) and the skin perfusion of hands in patients with acromegaly (AP) and healthy controls (HC).Methods: IL33 have been assessed in 40 AP and 40 HC. IL 33 was determined and skin perfusion of hands was assessed by laser speckle contrast analysis (LASCA) in both populations.Results: IL33 was significantly higher in AP compared to HC [45.72 pg/ml (IQR 28.74–60.86) vs 14 pg/ml (IQR 6.5535); p < 0.05]. At LASCA, peripheral blood perfusion (PBP) was significantly lower in AP compared to HC [53.39 pU (IQR 40.94–65.44) vs 87 pU (IQR 80–98) p < 0.001]. The median values of ROI1, ROI2 and ROI3 were significantly lower in AP compared to HC [97.32 pU (IQR 50.89–121.69) vs 131 pU (IQR 108–135); p < 0.001], [58.68 pU (IQR 37.72–84.92) vs 83 pU (IQR 70–89), p < 0.05] and HC [52.16 (34.47–73.78) vs 85 (78–98), p < 0.001], respectively. The proximal–distal gradient (PDG) was observed in 18 of 40 (45%) AP.Conclusion: Serum IL33 is higher in AP compared to HC; conversely a reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction, strictly dependent on acromegaly and are not influenced by the choice of treatment.