학술논문
Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes
Document Type
article
Author
Kapisi, James; Kakuru, Abel; Jagannathan, Prasanna; Muhindo, Mary K; Natureeba, Paul; Awori, Patricia; Nakalembe, Miriam; Ssekitoleko, Richard; Olwoch, Peter; Ategeka, John; Nayebare, Patience; Clark, Tamara D; Rizzuto, Gabrielle; Muehlenbachs, Atis; Havlir, Diane V; Kamya, Moses R; Dorsey, Grant; Gaw, Stephanie L
Source
Malaria Journal. 16(1)
Subject
Language
Abstract
BackgroundMalaria in pregnancy has been associated with maternal morbidity, placental malaria, and adverse birth outcomes. However, data are limited on the relationships between longitudinal measures of malaria during pregnancy, measures of placental malaria, and birth outcomes.MethodsThis is a nested observational study of data from a randomized controlled trial of intermittent preventive therapy during pregnancy among 282 participants with assessment of placental malaria and delivery outcomes. HIV-uninfected pregnant women were enrolled at 12-20 weeks of gestation. Symptomatic malaria during pregnancy was measured using passive surveillance and monthly detection of asymptomatic parasitaemia using loop-mediated isothermal amplification (LAMP). Placental malaria was defined as either the presence of parasites in placental blood by microscopy, detection of parasites in placental blood by LAMP, or histopathologic evidence of parasites or pigment. Adverse birth outcomes assessed included low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA) infants.ResultsThe 282 women were divided into three groups representing increasing malaria burden during pregnancy. Fifty-two (18.4%) had no episodes of symptomatic malaria or asymptomatic parasitaemia during the pregnancy, 157 (55.7%) had low malaria burden (0-1 episodes of symptomatic malaria and