학술논문
Evaluating the Outcomes of Active Surveillance in Grade Group 2 Prostate Cancer: Prospective Results from the Canary PASS Cohort
Document Type
article
Author
Malaret, Adrian J Waisman; Chang, Peter; Zhu, Kehao; Zheng, Yingye; Newcomb, Lisa F; Liu, Menghan; McKenney, Jesse K; Brooks, James D; Carroll, Peter; Dash, Atreya; Filson, Christopher P; Gleave, Martin E; Liss, Michael; Martin, Frances M; Morgan, Todd M; Nelson, Peter S; Lin, Daniel W; Wagner, Andrew A
Source
Investigative Urology. 207(4)
Subject
Language
Abstract
PurposeActive surveillance (AS) for grade group (GG) 2 patients is not yet well defined. We sought to compare clinical outcomes of men with GG1 and GG2 prostate cancer undergoing AS in a large prospective North American cohort.Materials and methodsParticipants were prospectively enrolled in an AS study with protocol-directed followup at 10 centers in the U.S. and Canada. We evaluated time from diagnosis to biopsy grade reclassification and time to treatment. In men treated after initial surveillance, adverse pathology and recurrence were also analyzed.ResultsAt diagnosis, 154 (9%) had GG2 and 1,574 (91%) had GG1. Five-year reclassification rates were similar between GG2 and GG1 (30% vs 37%, p=0.11). However, more patients with GG2 were treated at 5 years (58% vs 34%, p