학술논문
Large-scale association analyses identify host factors influencing human gut microbiome composition
Document Type
article
Author
Kurilshikov, Alexander; Medina-Gomez, Carolina; Bacigalupe, Rodrigo; Radjabzadeh, Djawad; Wang, Jun; Demirkan, Ayse; Le Roy, Caroline I; Raygoza Garay, Juan Antonio; Finnicum, Casey T; Liu, Xingrong; Zhernakova, Daria V; Bonder, Marc Jan; Hansen, Tue H; Frost, Fabian; Rühlemann, Malte C; Turpin, Williams; Moon, Jee-Young; Kim, Han-Na; Lüll, Kreete; Barkan, Elad; Shah, Shiraz A; Fornage, Myriam; Szopinska-Tokov, Joanna; Wallen, Zachary D; Borisevich, Dmitrii; Agreus, Lars; Andreasson, Anna; Bang, Corinna; Bedrani, Larbi; Bell, Jordana T; Bisgaard, Hans; Boehnke, Michael; Boomsma, Dorret I; Burk, Robert D; Claringbould, Annique; Croitoru, Kenneth; Davies, Gareth E; van Duijn, Cornelia M; Duijts, Liesbeth; Falony, Gwen; Fu, Jingyuan; van der Graaf, Adriaan; Hansen, Torben; Homuth, Georg; Hughes, David A; Ijzerman, Richard G; Jackson, Matthew A; Jaddoe, Vincent WV; Joossens, Marie; Jørgensen, Torben; Keszthelyi, Daniel; Knight, Rob; Laakso, Markku; Laudes, Matthias; Launer, Lenore J; Lieb, Wolfgang; Lusis, Aldons J; Masclee, Ad AM; Moll, Henriette A; Mujagic, Zlatan; Qibin, Qi; Rothschild, Daphna; Shin, Hocheol; Sørensen, Søren J; Steves, Claire J; Thorsen, Jonathan; Timpson, Nicholas J; Tito, Raul Y; Vieira-Silva, Sara; Völker, Uwe; Völzke, Henry; Võsa, Urmo; Wade, Kaitlin H; Walter, Susanna; Watanabe, Kyoko; Weiss, Stefan; Weiss, Frank U; Weissbrod, Omer; Westra, Harm-Jan; Willemsen, Gonneke; Payami, Haydeh; Jonkers, Daisy MAE; Arias Vasquez, Alejandro; de Geus, Eco JC; Meyer, Katie A; Stokholm, Jakob; Segal, Eran; Org, Elin; Wijmenga, Cisca; Kim, Hyung-Lae; Kaplan, Robert C; Spector, Tim D; Uitterlinden, Andre G; Rivadeneira, Fernando; Franke, Andre; Lerch, Markus M; Franke, Lude; Sanna, Serena; D’Amato, Mauro; Pedersen, Oluf
Source
Nature Genetics. 53(2)
Subject
Language
Abstract
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P