학술논문

Recognition and control of Mycobacterium tuberculosis-infected cells: from basics to the clinic: a NIAID/WGNV workshop report 2023
Document Type
article
Source
Subject
Medical Microbiology
Biomedical and Clinical Sciences
Immunology
Vaccine Related
Infectious Diseases
Prevention
Rare Diseases
HIV/AIDS
Orphan Drug
Tuberculosis Vaccine
Emerging Infectious Diseases
Immunization
Tuberculosis
Biodefense
Prevention of disease and conditions
and promotion of well-being
3.4 Vaccines
Infection
Good Health and Well Being
Language
Abstract
Vaccination is crucial for the control of tuberculosis (TB), and safe, more effective, and accessible vaccines against Mycobacterium tuberculosis (Mtb) infection are critically needed to achieve TB control milestones envisioned in the End TB Strategy. TB vaccine research and development faces numerous challenges including, but not limited to, insufficient knowledge of the most informative antigens to prioritize as potential vaccine candidates, lack of defined correlates of protection, and incomplete knowledge of anatomical and cellular locations of the Mtb-infected cell in vivo, among others. To take stock of the progress, challenges, and opportunities in TB vaccine R&D, the Stop TB Partnership Working Group on New TB Vaccines (WGNV), in partnership with the National Institute of Allergy and Infectious Diseases (NIAID) cohosted a two-day virtual workshop on 13–14 June 2023 with experts from all over the world. In this report, we summarize key themes and discussions from the meeting, highlighting progress and gaps in the TB vaccine research.