학술논문
Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis
Document Type
article
Author
Initiative, International Glossina Genome; Attardo, Geoffrey M; Abila, Patrick P; Auma, Joanna E; Baumann, Aaron A; Benoit, Joshua B; Brelsfoard, Corey L; Ribeiro, José MC; Cotton, James A; Pham, Daphne QD; Darby, Alistair C; Van Den Abbeele, Jan; Denlinger, David L; Field, Linda M; Nyanjom, Steven RG; Gaunt, Michael W; Geiser, Dawn L; Gomulski, Ludvik M; Haines, Lee R; Hansen, Immo A; Jones, Jeffery W; Kibet, Caleb K; Kinyua, Johnson K; Larkin, Denis M; Lehane, Michael J; Rio, Rita VM; Macdonald, Sandy J; Macharia, Rosaline W; Malacrida, Anna R; Marco, Heather G; Marucha, Kevin K; Masiga, Daniel K; Meuti, Megan E; Mireji, Paul O; Obiero, George FO; Koekemoer, Jacobus JO; Okoro, Chinyere K; Omedo, Irene A; Osamor, Victor C; Balyeidhusa, Apollo SP; Peyton, Justin T; Price, David P; Quail, Michael A; Ramphul, Urvashi N; Rawlings, Neil D; Riehle, Michael A; Robertson, Hugh M; Sanders, Mandy J; Scott, Maxwell J; Dashti, Zahra Jalali Sefid; Snyder, Anna K; Srivastava, Tulika P; Stanley, Eleanor J; Swain, Martin T; Hughes, Daniel ST; Tarone, Aaron M; Taylor, Todd D; Telleria, Erich L; Thomas, Gavin H; Walshe, Deirdre P; Wilson, Richard K; Winzerling, Joy J; Acosta-Serrano, Alvaro; Aksoy, Serap; Arensburger, Peter; Aslett, Martin; Bateta, Rosemary; Benkahla, Alia; Berriman, Matthew; Bourtzis, Kostas; Caers, Jelle; Caljon, Guy; Christoffels, Alan; Falchetto, Marco; Friedrich, Markus; Fu, Shuhua; Gäde, Gerd; Githinji, George; Gregory, Richard; Hall, Neil; Harkins, Gordon; Hattori, Masahira; Hertz-Fowler, Christiane; Hide, Winston; Hu, Wanqi; Imanishi, Tadashi; Inoue, Noboru; Jonas, Mario; Kawahara, Yoshihiro; Koffi, Mathurin; Kruger, Adele; Lawson, Daniel; Lehane, Stella; Lehväslaiho, Heikki; Luiz, Thiago; Makgamathe, Mmule; Malele, Imna; Manangwa, Oliver; Manga, Lucien; Megy, Karyn
Source
Science. 344(6182)
Subject
Language
Abstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.