학술논문
Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma.
Document Type
article
Author
Israel, E; Drazen, JM; Liggett, SB; Boushey, HA; Cherniack, RM; Chinchilli, VM; Cooper, DM; Fahy, JV; Fish, JE; Ford, JG; Kraft, M; Kunselman, S; Lazarus, SC; Lemanske, RF; Martin, RJ; McLean, DE; Peters, SP; Silverman, EK; Sorkness, CA; Szefler, SJ; Weiss, ST; Yandava, CN; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
Source
International archives of allergy and immunology. 124(1-3)
Subject
Language
Abstract
BackgroundRegular use of inhaled beta-adrenergic agonists may have adverse effects in some asthma patients. Polymorphisms of the beta(2)-adrenergic receptor (beta(2)-AR) can affect its regulation; however, results of smaller studies of the effects of such polymorphisms on response to beta-agonist therapy have been inconsistent.MethodsWe examined the possible effects of polymorphisms at codons 16 (beta(2)-AR-16) and 27 (beta(2)-AR-27) on response to albuterol by genotyping 190 asthmatics who had participated in a trial of regular versus as-needed albuterol use.ResultsDuring the 16-week treatment period, patients homozygous for arginine (Arg/Arg) at beta(2)-AR-16 who used albuterol regularly had a small decline in morning peak expiratory flow (AM PEF). This effect was magnified during a 4-week run-out period, when all patients returned to as-needed albuterol only. By the end of the study, Arg/Arg subjects who had used albuterol regularly had an AM PEF 30.5 +/- 12.1 liters/min lower (p = 0.012) than Arg/Arg patients who had used albuterol as needed only. Subjects homozygous for glycine at beta(2)-AR-16 showed no such decline. Evening PEF also declined in the Arg/Arg regular but not in as-need albuterol users. No significant differences between regular and as-needed treatment were associated with polymorphisms at beta(2)-AR-27.ConclusionsPolymorphisms of the beta(2)-AR may influence airway responses to regular inhaled beta-agonist treatment.