학술논문
COVID-19 in solid organ transplant: A multi-center cohort study
Document Type
article
Author
Kates, Olivia S; Haydel, Brandy M; Florman, Sander S; Rana, Meenakshi M; Chaudhry, Zohra S; Ramesh, Mayur S; Safa, Kassem; Kotton, Camille Nelson; Blumberg, Emily A; Besharatian, Behdad D; Tanna, Sajal D; Ison, Michael G; Malinis, Maricar; Azar, Marwan M; Rakita, Robert M; Morilla, Jose A; Majeed, Aneela; Sait, Afrah S; Spaggiari, Mario; Hemmige, Vagish; Mehta, Sapna A; Neumann, Henry; Badami, Abbasali; Goldman, Jason D; Lala, Anuradha; Hemmersbach-Miller, Marion; McCort, Margaret E; Bajrovic, Valida; Ortiz-Bautista, Carlos; Friedman-Moraco, Rachel; Sehgal, Sameep; Lease, Erika D; Fisher, Cynthia E; Limaye, Ajit P; Arya, Akanksha; Jeng, Amy; Kuo, Alexander; Luk, Alfred; Puing, Alfredo G; Rossi, Ana P; Brueckner, Andrew J; Multani, Ashrit; Keller, Brian C; Derringer, Darby; Florescu, Diana F; Dominguez, Edward A; Sandoval, Elena; Bilgili, Erin P; Hashim, Faris; Silveira, Fernanda P; Haidar, Ghady; Joharji, Hala G; Murad, Haris F; Gani, Imran Yaseen; el-amm, Jose-Marie; Kahwaji, Joseph; Popoola, Joyce; Yabu, Julie M; Hughes, Kailey; Saharia, Kapil K; Gajurel, Kiran; Bowman, Lyndsey J; Veroux, Massimiliano; Morales, Megan K; Fung, Monica; Theodoropoulos, Nicole M; de la Cruz, Oveimar; Kapoor, Rajan; La Hoz, Ricardo M; Allam, Sridhar R; Vora, Surabhi B; McCarty, Todd P; Anderson-Haag, Tracy; Malhotra, Uma; Kelly, Ursula M; Bhandaram, Vidya; Bennett, William M; Lominadze, Zurabi
Source
Clinical Infectious Diseases. 73(11)
Subject
Language
Abstract
BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has led to significant reductions in transplantation, motivated in part by concerns of disproportionately more severe disease among solid organ transplant (SOT) recipients. However, clinical features, outcomes, and predictors of mortality in SOT recipients are not well described.MethodsWe performed a multicenter cohort study of SOT recipients with laboratory-confirmed COVID-19. Data were collected using standardized intake and 28-day follow-up electronic case report forms. Multivariable logistic regression was used to identify risk factors for the primary endpoint, 28-day mortality, among hospitalized patients.ResultsFour hundred eighty-two SOT recipients from >50 transplant centers were included: 318 (66%) kidney or kidney/pancreas, 73 (15.1%) liver, 57 (11.8%) heart, and 30 (6.2%) lung. Median age was 58 (interquartile range [IQR] 46-57), median time post-transplant was 5 years (IQR 2-10), 61% were male, and 92% had ≥1 underlying comorbidity. Among those hospitalized (376 [78%]), 117 (31%) required mechanical ventilation, and 77 (20.5%) died by 28 days after diagnosis. Specific underlying comorbidities (age >65 [adjusted odds ratio [aOR] 3.0, 95% confidence interval [CI] 1.7-5.5, P