학술논문
Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
Document Type
article
Author
Favre, Pauline; Pauling, Melissa; Stout, Jacques; Hozer, Franz; Sarrazin, Samuel; Abé, Christoph; Alda, Martin; Alloza, Clara; Alonso-Lana, Silvia; Andreassen, Ole A; Baune, Bernhard T; Benedetti, Francesco; Busatto, Geraldo F; Canales-Rodríguez, Erick J; Caseras, Xavier; Chaim-Avancini, Tiffany Moukbel; Ching, Christopher RK; Dannlowski, Udo; Deppe, Michael; Eyler, Lisa T; Fatjo-Vilas, Mar; Foley, Sonya F; Grotegerd, Dominik; Hajek, Tomas; Haukvik, Unn K; Howells, Fleur M; Jahanshad, Neda; Kugel, Harald; Lagerberg, Trine V; Lawrie, Stephen M; Linke, Julia O; McIntosh, Andrew; Melloni, Elisa MT; Mitchell, Philip B; Polosan, Mircea; Pomarol-Clotet, Edith; Repple, Jonathan; Roberts, Gloria; Roos, Annerine; Rosa, Pedro GP; Salvador, Raymond; Sarró, Salvador; Schofield, Peter R; Serpa, Mauricio H; Sim, Kang; Stein, Dan J; Sussmann, Jess E; Temmingh, Henk S; Thompson, Paul M; Verdolini, Norma; Vieta, Eduard; Wessa, Michele; Whalley, Heather C; Zanetti, Marcus V; Leboyer, Marion; Mangin, Jean-François; Henry, Chantal; Duchesnay, Edouard; Houenou, Josselin
Source
Neuropsychopharmacology. 44(13)
Subject
Language
Abstract
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R2 = 0.041, Pcorr