학술논문
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
Document Type
article
Author
Deng, Xianding; Gu, Wei; Federman, Scot; du Plessis, Louis; Pybus, Oliver G; Faria, Nuno; Wang, Candace; Yu, Guixia; Bushnell, Brian; Pan, Chao-Yang; Guevara, Hugo; Sotomayor-Gonzalez, Alicia; Zorn, Kelsey; Gopez, Allan; Servellita, Venice; Hsu, Elaine; Miller, Steve; Bedford, Trevor; Greninger, Alexander L; Roychoudhury, Pavitra; Starita, Lea M; Famulare, Michael; Chu, Helen Y; Shendure, Jay; Jerome, Keith R; Anderson, Catie; Gangavarapu, Karthik; Zeller, Mark; Spencer, Emily; Andersen, Kristian G; MacCannell, Duncan; Paden, Clinton R; Li, Yan; Zhang, Jing; Tong, Suxiang; Armstrong, Gregory; Morrow, Scott; Willis, Matthew; Matyas, Bela T; Mase, Sundari; Kasirye, Olivia; Park, Maggie; Masinde, Godfred; Chan, Curtis; Yu, Alexander T; Chai, Shua J; Villarino, Elsa; Bonin, Brandon; Wadford, Debra A; Chiu, Charles Y
Source
Science. 369(6503)
Subject
Language
Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with >365,000 cases in California as of 17 July 2020. We investigated the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning nine counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least seven different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington state, with lack of a predominant lineage and limited transmission among communities. Lineages associated with outbreak clusters in two counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain the spread of SARS-CoV-2 in California and other states.