학술논문

Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study
Document Type
article
Author
McGrath, Lauren MYu, DongmeiMarshall, ChristianDavis, Lea KThiruvahindrapuram, BhoomaLi, BingbinCappi, CarolinaGerber, GloriaWolf, AaronSchroeder, Frederick AOsiecki, LisaO'Dushlaine, ColmKirby, AndrewIllmann, CorneliaHaddad, StephenGallagher, PatienceFagerness, Jesen ABarr, Cathy LBellodi, LauraBenarroch, FortuBienvenu, O JosephBlack, Donald WBloch, Michael HBruun, Ruth DBudman, Cathy LCamarena, BeatrizCath, Danielle CCavallini, Maria CChouinard, SylvainCoric, VladimirCullen, BernadetteDelorme, RichardDenys, DamiaanDerks, Eske MDion, YvesRosário, Maria CEapen, ValsamaEvans, PatrickFalkai, PeterFernandez, Thomas VGarrido, HelenaGeller, DanielGrabe, Hans JGrados, Marco AGreenberg, Benjamin DGross-Tsur, VardaGrünblatt, EdnaHeiman, Gary AHemmings, Sian MJHerrera, Luis DHounie, Ana GJankovic, JosephKennedy, James LKing, Robert AKurlan, RogerLanzagorta, NuriaLeboyer, MarionLeckman, James FLennertz, LeonhardLochner, ChristineLowe, Thomas LLyon, Gholson JMacciardi, FabioMaier, WolfgangMcCracken, James TMcMahon, WilliamMurphy, Dennis LNaarden, Allan LNeale, Benjamin MNurmi, ErikaPakstis, Andrew JPato, Michele TPato, Carlos NPiacentini, JohnPittenger, ChristopherPollak, YehudaReus, Victor IRichter, Margaret ARiddle, MarkRobertson, Mary MRosenberg, DavidRouleau, Guy ARuhrmann, StephanSampaio, Aline SSamuels, JackSandor, PaulSheppard, BrookeSinger, Harvey SSmit, Jan HStein, Dan JTischfield, Jay AVallada, HomeroVeenstra-VanderWeele, JeremyWalitza, SusanneWang, YingWendland, Jens RShugart, Yin YaoMiguel, Euripedes CNicolini, HumbertoOostra, Ben A
Source
Journal of the American Academy of Child & Adolescent Psychiatry. 53(8)
Subject
Human Genome
Genetics
Brain Disorders
Serious Mental Illness
Neurodegenerative
Mental Health
Tourette Syndrome
Neurosciences
Intellectual and Developmental Disabilities (IDD)
Aetiology
2.1 Biological and endogenous factors
Mental health
Adolescent
DNA Copy Number Variations
Diagnostic and Statistical Manual of Mental Disorders
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Obsessive-Compulsive Disorder
Polymorphism
Single Nucleotide
Tourette syndrome
obsessive-compulsive disorder
copy number variation
genetics
16p13.11
Medical and Health Sciences
Psychology and Cognitive Sciences
Developmental & Child Psychology
Language
Abstract
ObjectiveObsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (