부산대학교 도서관

ABSTRACT: SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities preventing vascular ageing. The expression and function of SIRT1 in endothelial cells are downregulated with age, in turn causing early vascular ageing and predisposing various vascular abnormalities. Overexpression of SIRT1 in the vascular endothelium prevents ageing-associated endothelial dysfunction and senescence, thus the development of hypertension and atherosclerosis. Numerous efforts have been directed to increase SIRT1 signaling as a potential strategy for different ageing-associated diseases. However, the complex mechanisms underlying the regulation of SIRT1 have posed a significant challenge towards the design of specific and effective therapeutics. This review aimed to provide a summary on the regulation and function of SIRT1 in the vascular endothelium and to discuss the different approaches targeting this molecule for the prevention and treatment of age-related cardiovascular and cerebrovascular diseases.